The COVID-19 pandemic has created a global call to action to pharmaceutical companies for the development of a suitable vaccine. In the development of such vaccine(s), understanding the biostability and kinetics/thermodynamics of very small and dilute protein solutions is necessary. Thermal stability is important for the performance of proteins and other biostructures within vaccines. Denaturing of protein structure can limit vaccine function and thus reduce effectiveness of any developed vaccine within the pharmaceutical sector.
C-Therm Technologies Ltd. has worked closely with the world-leader in calorimetry, Setaram Instrumentation, for over a decade. With the SETARAM µDSC VII (See Figure 1) equipped with the unique Calvet sensor’s 93-95% heat detection efficiency, small and precise thermodynamic events can be observed at nanomolar concentrations. Compared to traditional pan-style calorimetry instrumentation, the 3D Calvet sensor offers substantially better sensitivity for the purpose of studying vaccine formulations, or thermal stability of finalized products. With increased urgency in the development of a vaccine for COVID-19, the µDSC VII and µSC DSC instrumentation offer flexibility to measure solids, liquids, solutions and more. Different sample cells can provide mixing, or standard isothermal measurement runs, perfect for monitoring enzymatic reactions in kinetic or isothermal measurement modes. Additionally, the µSC DSC offers higher capacity for running multiple samples at the same time, allowing for comparison between different formulations for vaccine or other biomolecule solutions. Compared to other pan style or capillary style DSC instruments, SETARAMs calorimetry offerings provide versatility without compromising sensitivity and have become a benchmark tool for studying thermal stability of vaccine formulations within the pharmaceutical sector.
C-Therm is offering access to its Setaram calorimeter via its lab services in support of research organizations developing COVID-19 vaccines and can lend considerable expertise in outfitting labs with the high sensitivity tools for accelerating the development of vaccines.